(Download) Indian National Biology Olympiad (INBO) Question Papers 2017

Question paper
Exam Name : INBO Olympiad Question Papers 2017

Section A

1. (1 point) In a lung cancer cell line, it is observed that a single point mutation (cysteine to phenylalanine) makes a protein defective in phosphorylation function.
The loss of function is most likely due to:
a. increase in solubility of the protein in aqueous environment.
b. alteration of protein conformation essential for protein-protein interaction.
c. increase in the net charge of the protein leading to loss of active site.
d. decrease in hydrophobic interactions of the protein with other proteins.

2. (1 point) Which of the following proteins are likely to be active during mitosis?
i. Telomerase
ii. Primase
iii. Topoisomerase
iv. Kinesin
a. ii, iii & iv only
b. iii & iv only
c. i, ii & iii only
d. only iv

3. (1 point) A tuberculosis patient died within a few minutes of second intravenous administration of streptomycin and the post-mortem report gave anaphylactic shock as the cause of death. 
This is explained as:
a. a sudden surge in IgM synthesis leading to complement activation causing fatal drop in blood pressure.
b. a vigorous precipitation of soluble antigens in body fluids triggered by the IgA insurgence leading to blockage of capillaries to vital organs.
c. IgE induced mast cell degranulation triggering abrupt dilation of peripheral blood vessels resulting in a precipitous drop in blood pressure.
d. IgD induced agglutination of antigen-bearing cells in vital organs leading to multi-organ failure. 

4. (1 point) Apoptosis is programmed cell death characterized by the formation of apoptotic bodies whereas necrosis is characterized by bursting of cells. Which of the following condition/s lead/s to necrosis? 
i. Gaps and nicks formed in DNA during replication cannot be repaired.
ii. Developing neurons fail to make synapses with neighbouring cells.
iii. Heart muscle cells damaged by oxygen depletion followed by cardiac infarction.
a. i and ii
b. ii and iii
c. i only
d. iii only

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